Palladium catalyzed a formal cycloaddition reaction forming γ-lactam from allylic carbonates and sulfur ylides, suggesting broad synthetic applications.
In this paper, we reported a palladium-catalyzed formal (4 + 1) cycloaddition reaction between amido-tethered allylic carbonates and sulfur ylides. The reaction worked well to provide γ-lactam compounds in satisfactory yields and displayed good compatibility to a wide range of functional groups. The synthetic value of the reaction was demonstrated through scale-up reaction and further transformation. A plausible reaction mechanism was also proposed.
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Wang et al. (2025) studied this question.
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