Targeted literature review finds low pseudosepsis rates in knee osteoarthritis patients receiving hyaluronic acid injections, indicating minimal risk associated with hylan G-F 20.
Hyaluronic acid injections for knee osteoarthritis patients can result in pseudosepsis. A targeted literature review was conducted to determine the rate of pseudosepsis in patients receiving intra-articular hyaluronic acid, particularly hylan G-F 20 (SYNVISC®). Articles were identified through Embase using predefined search strategies. Pseudosepsis event rate was calculated by dividing the number of reported events by the total number of intra-articular injections. The pseudosepsis event rate ranged from 0% to 5.6% per injection; most treatment groups had an event rate of ≤2% per injection. Pseudosepsis event rates were low across studies for patients treated with hyaluronic acid, including hylan G-F 20.
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Sherman et al. (2025) studied this question.
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