Unravelling the molecular landscape of polycystic ovary syndrome (PCOS) and role of inflammation through transcriptomics analysis of human ovarian granulosa cells.
Transcriptomics analysis reveals inflammatory gene expression changes in granulosa cells of women with PCOS, suggesting a role for inflammation in disease progression.
Key Points
Polycystic ovary syndrome (PCOS) is linked to inflammation, affecting ovarian granulosa cells' gene expression.
RNA-seq analysis identified key inflammatory genes such as SPI1 and HSPB1 significantly upregulated in PCOS.
Pathway enrichment showed increased activation in pathways related to inflammation, insulin resistance, and hyperlipidemia in PCOS.
Findings suggest a complex interplay between inflammation, obesity, and metabolic disorders in women with PCOS.