August 14, 2025

Efficacy and Safety of Seltorexant in Insomnia Disorder: A Randomized Clinical Trial.

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Seltorexant, at doses of 10 mg and 20 mg, significantly improved sleep initiation measured by latency to persistent sleep.
Treatment-emergent adverse events were fewer in the seltorexant group compared to placebo and zolpidem, suggesting better safety.
The study involved 364 participants aged 18-85, who received nightly doses of seltorexant or placebo for 14 days.
Improvements in sleep measures were sustained through night 13 for seltorexant, highlighting its effectiveness over zolpidem.

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Implication

Randomized clinical trial shows seltorexant improves sleep initiation in adults with insomnia, indicating potential as a safer alternative to zolpidem.

Cite This Study

Mesens et al. (2025) studied this question.

synapsesocial.com/papers/689fc6852abb084d53ed2425 https://doi.org/10.1001/jamapsychiatry.2025.1999

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Implication

Randomized clinical trial shows seltorexant improves sleep initiation in adults with insomnia, indicating potential as a safer alternative to zolpidem.

Efficacy and Safety of Seltorexant in Insomnia Disorder: A Randomized Clinical Trial.

Key Points

Discussion

Implication

Cite This Study

Efficacy and Safety of Seltorexant in Insomnia Disorder: A Randomized Clinical Trial.

Key Points

Discussion

Implication

Cite This Study

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