YCT-529 shows 99% effectiveness in preventing pregnancies in mice, implying potential for human male contraception.
YCT-529 reversibly reduces sperm counts to infertility levels in mice and non-human primates. Mice mating studies demonstrated 99% effectiveness in preventing pregnancies. YCT-529 has completed a first-in-class, double-blind, placebo-controlled Phase I clinical safety study in men and is currently being investigated in a Phase Ib/IIa clinical study.
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Taher et al. (2025) studied this question.
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