Clinical trial demonstrates good integration and safety of 3D-printed PCL/β-TCP scaffolds for craniofacial reconstruction, implying potential for wider use.
This study presents the first clinical application in China of a 3D-printed polycaprolactone (PCL)/ β-tricalcium phosphate(β-TCP) composite scaffold for craniofacial bone defect reconstruction. The clinical trial involved 2 patients with varying craniofacial defects who underwent reconstruction using customized PCL/β-TCP composite scaffolds. The scaffolds were designed based on CT imaging and fabricated through low-temperature 3D printing, ensuring personalized fit and biocompatibility. Postoperative follow-up demonstrated good scaffold integration, tissue ingrowth, and patient satisfaction without serious complications. This pioneering trial confirms the feasibility and safety of PCL/β-TCP composite scaffolds for craniofacial reconstruction, laying a foundation for broader clinical applications.
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Hu et al. (2025) studied this question.
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