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August 14, 2025

In Vivo Evaluation of Melasma Pathologic Features and Treatment Response by 2-Photon Microscopy.

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Authors

XNXiaoli NingJYJungang YangHOHongfei Ouyang

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Overview

Observational study shows improved pathologic features and treatment response in melasma cases using 2-photon microscopy and hydroquinone, indicating alternative management strategies.

Key Points

  • Melasma lesions showed significant increases in melanin content across epidermal layers during in vivo assessment.
  • Hydroquinone treatment led to a 29.81% decrease in mMASI scores and a 36.16% decrease in dermoscopic scores after 12 weeks.
  • Utilization of 2-photon microscopy provided insights into cellular-level changes in melasma pathologic features.
  • Findings suggest that TPM may enhance clinical approaches to managing pigmentary disorders like melasma.

Cite This Study

Ning et al. (2025) studied this question.

synapsesocial.com/papers/689fc6912abb084d53ed2646https://doi.org/10.1001/jamadermatol.2025.2790
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