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October 2, 2025Pigment Cell & Melanoma Research

Noninvasive Assessment of Melasma Pathological Features: Side‐By‐Side Comparison of Two‐Photon Microscopy and Reflectance Confocal Microscopy

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Authors

XNXiaoli NingJYJungang YangHOHongfei Ouyang

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Overview

Cross-sectional study compares two-photon microscopy and reflectance confocal microscopy for melasma features, suggesting complementary diagnostic roles.

Key Points

  • TPM and RCM demonstrated substantial agreement in assessing increased epidermal melanin and activated melanocytes.
  • In patients with melasma, TPM excelled in visualizing intracellular melanin distribution compared to RCM.
  • Epidermal melanin content quantified by TPM correlated positively with the melanin index and negatively with the individual typology angle.
  • RCM detected more dermal inflammatory cells in active melasma compared to stable cases, reflecting disease activity.

Cite This Study

Ning et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3183cbc991d0a220f3https://doi.org/10.1111/pcmr.70057
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