August 14, 2025

Thiazole substitution of a labile amide bond-a new option toward antiplasmodial pantothenamide-mimics.

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Several novel pantothenamide-mimics with thiazole substitution were synthesized and showed sub-micromolar antiplasmodial activity.
Out of 23 compounds tested, some effectively inhibited Plasmodium falciparum proliferation while remaining non-toxic to human cells.
Kinetic studies revealed these compounds as substrates for HsPanK3, although with lower affinity than pantothenate.
Selectivity was observed as the most effective compound bound PfPanK with a 120-fold higher affinity than HsPanK, enhancing its potential as an antimalarial.

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Implication

New pantothenamide-mimics demonstrate sub-micromolar antiplasmodial activity in Plasmodium falciparum, indicating potential for improved malaria treatment.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/689fc6912abb084d53ed26a3 https://doi.org/10.1128/aac.00331-25

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Implication

New pantothenamide-mimics demonstrate sub-micromolar antiplasmodial activity in Plasmodium falciparum, indicating potential for improved malaria treatment.

Thiazole substitution of a labile amide bond-a new option toward antiplasmodial pantothenamide-mimics.

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Implication

Cite This Study

Thiazole substitution of a labile amide bond-a new option toward antiplasmodial pantothenamide-mimics.

Key Points

Discussion

Implication

Cite This Study

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