August 15, 2025Open Access

A Novel Cell-Free DNA Fragmentomics Assay and Its Application for Monitoring Disease Progression in Real-Time for Stage IV Cancer Patients

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Prospective study reveals a real-time PCR approach to monitor treatment efficacy in metastatic cancer, indicating quicker clinical decision-making.

The progression score model achieved an area under the curve of 0.93 for predicting disease progression.
Patients with a progression score above 90 showed a 92% incidence of progression, while those below 10 showed 95% non-progression.
Real-time quantitative PCR was used to analyze size-distributed cell-free DNA fragments in cancer patients.
This non-invasive assay can improve outcomes and reduce costs by detecting ineffective treatments earlier.

Sinha et al. (2025) studied this question.

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August 15, 2025Open Access

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Authors

Prospective study reveals a real-time PCR approach to monitor treatment efficacy in metastatic cancer, indicating quicker clinical decision-making.

The progression score model achieved an area under the curve of 0.93 for predicting disease progression.
Patients with a progression score above 90 showed a 92% incidence of progression, while those below 10 showed 95% non-progression.
Real-time quantitative PCR was used to analyze size-distributed cell-free DNA fragments in cancer patients.
This non-invasive assay can improve outcomes and reduce costs by detecting ineffective treatments earlier.

Sinha et al. (2025) studied this question.

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