Hydroamination achieves efficient Markovnikov addition of nitrogen heterocycles to olefins, indicating a promising reaction method.
A Brønsted acid‐catalyzed hydroamination of unactivated olefins has been developed, enabling the efficient Markovnikov addition of nitrogen heterocycles to olefins. This reaction utilizes a catalytic amount of trifluoroacetic acid (TFA) to produce a diverse array of N‐alkyl nitrogen heterocycles. The method is highly scalable, allowing for multigram synthesis, and a novel proton transfer species implicated in olefin activation has been identified.
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Feng et al. (2025) studied this question.
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