This research demonstrates a novel method for synthesizing 3,3-disubstituted tetrahydroisoquinolines using base-mediated annulation, suggesting promising synthetic potential.
In this research we represented a simple and elegant method for 3,3‐disubstituted THIQs via base‐mediated [4 + 2] annulation of α‐amino acid ester derivatives and 1,2‐bis(bromomethyl)benzene under mild conditions. This protocol features good substrate tolerance, mild conditions and moderate to excellent yields. The synthetic potential of this protocol was highlighted by scale‐up experiments and further structural elaboration.
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Feng et al. (2025) studied this question.
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