Clinical report highlights prognosis and treatment challenges in sinonasal undifferentiated carcinoma with intracranial extension, suggesting a need for multidisciplinary approaches.
Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive malignancy with poor prognosis, especially with intracranial extension. The authors report a 44-year-old male with T4B SNUC presenting with epistaxis, headache, and diplopia. Initial chemotherapy failed. He underwent combined craniofacial resection (transbasal and endonasal) with pericranial flap reconstruction and titanium mesh cranioplasty, followed by adjuvant chemoradiotherapy (weekly cisplatin). This case highlights the diagnostic challenges, the aggressive nature of SNUC, and the feasibility of radical multimodal treatment, including complex surgery, for extensive disease. Despite aggressive therapy, outcomes remain guarded, emphasizing the need for multidisciplinary management and further research into novel therapeutic strategies for this challenging entity.
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Santos et al. (2025) studied this question.
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