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August 11, 2025Journal of Modern OncologyOpen Access

Prognostic significance of primary and interval cytoreductive surgery in late-stage ovarian cancer. A retrospective study

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Authors

VZVarvara N. ZhurmanVladivostok State Medical UniversityВНВ. М. НечушкинаPrivolzhsky Research Medical UniversityAMAnna MaslennikovaRadiophysical Research Institute

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Implication

Retrospective analysis indicates better overall survival with primary cytoreduction in ovarian cancer patients, highlighting treatment timing's impact.

Key Points

  • Patients with late-stage ovarian cancer show better overall survival and progression-free survival with primary cytoreductive surgery.
  • Data from 467 patients revealed significant advantages for those receiving complete or optimal primary cytoreduction compared to interval cytoreduction.
  • Retrospective analysis revealed that neoadjuvant chemotherapy likely worsens treatment outcomes in advanced ovarian cancer cases.
  • Findings support the use of primary cytoreduction as the main approach for advanced ovarian cancer treatment, despite the risks associated with neoadjuvant chemotherapy.

Cite This Study

Zhurman et al. (2025) studied this question.

synapsesocial.com/papers/68a35ef30a429f7973328433https://doi.org/10.26442/18151434.2025.2.203174
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of the treatment effectiveness in patients with stage IIB–IIIB ovarian cancer2024 · 1 citations
  2. 2Guidelines and selection criteria for secondary cytoreductive surgery in patients with recurrent, platinum‐sensitive epithelial ovarian carcinoma2006 · 359 citations
  3. 3Debulking surgery in oncogynecology2016 · 2 citations
  4. 4Utilization of Primary Cytoreductive Surgery for Advanced-Stage Ovarian Cancer2024 · 21 citations