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August 11, 2025Journal of Modern OncologyOpen Access

Role of repeat biopsies of metastatic and recurrent lesions for the study of tumor heterogeneity in luminal breast cancer: Retrospective and prospective analyses

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Authors

MGM. I. GluzmanECE. A. ChistyakovaГРГ. А. Раскин

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Overview

Retrospective and prospective analyses show immunohistochemical discordance in luminal breast cancer, impacting treatment decisions.

Key Points

  • Discordance in immunohistochemical results was found in 57% of cases, leading to significant treatment changes.
  • Among 100 patients, subtype conversion occurred in 37% of cases, mainly from luminal A to B.
  • Analysis focused on clinical and morphological factors, revealing limited impact on discordance detection.
  • The findings support the necessity of repeat biopsies for tailoring therapies in luminal breast cancer patients.

Cite This Study

Gluzman et al. (2025) studied this question.

synapsesocial.com/papers/68a35ef30a429f797332847chttps://doi.org/10.26442/18151434.2025.2.203200
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