Etiology and Antibiotic Resistance of Microflora in Patients With Purulent Wounds

The objective of this study was to investigate the etiological composition and antibiotic resistance patterns of microbial flora in patients with purulent wounds for the purpose of developing a protocol for rational empirical antibiotic treatment. Material and methods. We have analyzed the results of microbiological tests performed on patients with purulent wounds treated at the Mogilev Regional Hospital between 2023 and 2024. Identification and susceptibility testing of microorganisms to antibiotics were performed using Vitek 2 Compact biochemical analysis systems (BioMerieux, France). Results. 511 isolates (40.8%) of Staphylococcus spp., 423 isolates (33.8%) of Enterobacteriaceae, 120 isolates (9.6%) P. aeruginosa, 109 isolates (8.7%) A. baumannii, 71 isolates (5.7%) Enterococcus, 16 isolates (1.4%) Streptococcus spp. were identified. The aerobic microorganisms showed multiple resistance to antibiotics. Based on these findings, a protocol for empirical antibiotic therapy in patients with infected wounds has been developed. Conclusions. The leading role in the etiology of microorganisms in patients with purulent wounds is played by Staphylococcus spp., Enterobacteriaceae, P. aeruginosa, and A. baumannii. There is a general tendency for the growth of the most dangerous pathogens of the “ESKAPE pathogen” group for patients. The representatives of the microflora isolated from purulent wounds have a high level of resistance to antibiotics. The developed protocol for empirical antibiotic therapy in patients with purulent wounds shows a high degree of clinical effectiveness.