AFM and force spectroscopy reveal cholesterol-induced asymmetry in DOPC membranes, suggesting implications for lipid behavior.
In the recent article, Adhyapak et al., used Atomic Force Microscopy (AFM) and Force Spectroscopy to investigate the influence of cholesterol on the phase state behaviour of fluid phase DOPC membranes and found that the excess cholesterol conditions (above 20%) can induce an asymmetry in the lipid bilayer leading to changes both topography and more significantly in the nanomechanical properties of the lipid bilayer.
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Bhat et al. (2025) studied this question.
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