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August 11, 2025Scientific ReportsOpen Access

Synthesis of piperazine-based benzimidazole derivatives as potent urease inhibitors and molecular docking studies

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Authors

DSDelaram ShahriarynejadTehran University of Medical SciencesNDNavid DastyaftehIran University of Medical SciencesFNFouzia NazJinnah University for Women

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Implication

Synthesis reveals potent urease inhibitors in piperazine-benzimidazole analogs, suggesting therapeutic potential.

Key Points

  • Almost all synthesized piperazine-benzimidazole derivatives displayed potent urease inhibitory activity, significantly exceeding standard thiourea.
  • The most effective compound showed an IC50 value of 0.15 µM, confirming its strong potential as a urease inhibitor.
  • A multistep synthesis process was used, starting from easily accessible precursors to create a diverse library of compounds.
  • Molecular docking studies indicated favorable interactions of compounds with the urease active site, supporting their development as therapeutic agents.

Cite This Study

Shahriarynejad et al. (2025) studied this question.

synapsesocial.com/papers/68a360e70a429f7973329719https://doi.org/10.1038/s41598-025-14723-4
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