Efficient protocol achieves moderate to excellent yields in bisphosphorylated quinoxalines, suggesting broad applicability in pharmaceutical applications.
An efficient protocol for synthesis of 2,3‐bisphosphoryltetrahydroquinoxalines via double C−H phosphorylation of quinoxalines under catalyst and light‐free conditions was developed. The described protocol could deliver a series of bisphosphonylated products in moderate to excellent yields. Moreover, the methodology is highly efficient and tolerant of a number of functional groups such as nitro, ester, carboxy, halogen, and hydroxyl groups. The reported methodology provided an extremely simple and efficient approach to obtain a variety of biphosphorylated quinoxalines as promising pharmaceutical skeletons and ligands in catalysis systems.
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Gan et al. (2025) studied this question.
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