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August 11, 2025JAMA Internal Medicine

Screening for Syphilis Infection in Persons With Moth-Eaten Alopecia

Xiaoting Song Jia-Xing Zheng Wei Liu

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Key Points

Recognizing moth-eaten alopecia is crucial in screening for secondary syphilis, aiding early detection and treatment.
The clinical clue of moth-eaten alopecia is often overlooked, yet it can indicate underlying syphilis infections.
Increased awareness among healthcare providers can facilitate better syphilis screening in patients exhibiting this symptom.
Patients presenting with alopecia should be evaluated for syphilis, improving health outcomes through timely intervention.

Implication

This Teachable Moment highlights the link between moth-eaten alopecia and secondary syphilis, suggesting improved screening practices.

Abstract

This Teachable Moment discusses the importance of recognizing the clinical clue of moth-eaten alopecia for secondary syphilis.

Discussion

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Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/68a360f20a429f7973329bba https://doi.org/10.1001/jamainternmed.2025.3844

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Moth eaten alopecia as the only manifestation of syphilis: a case from Nepal2024 · 1 citations
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4Syphilitic Alopecia Through the Dermoscope: A Series of two Cases2025
5Secondary syphilis presenting with alopecia and leukoderma in a stable HIV-positive patient in a resource-limited setting: a case report2024 · 2 citations