August 12, 2025Annals of HematologyOpen Access

Clinical characteristics and outcome of pediatric patients with high-risk acute promyelocytic leukemia, with special focus on risk factors of early death

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QGQin-Li GaoFujian Medical University YCYiqiao ChenFujian Medical University SLShaohua LeFujian Medical University

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Retrospective analysis reveals 5-year overall survival of 78.1% in pediatric high-risk APL, indicating ongoing challenges with early death risk factors.

Key Points

Early death remains a significant challenge in high-risk acute promyelocytic leukemia, linked to higher rates of white blood cell counts and prolonged prothrombin time.
The 5-year overall survival rate of pediatric patients with high-risk APL is estimated at 78.1%, demonstrating the effectiveness of treatment despite high risk.
Thirty-two pediatric patients diagnosed with high-risk APL were assessed, revealing a 21.8% early death occurrence during induction chemotherapy.
Significant risk factors for early death include rapid disease progression, increased white blood cell counts, and female gender, indicating need for closer monitoring.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68a3633d0a429f7973329ebb https://doi.org/10.1007/s00277-025-06528-2

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Implication

Retrospective analysis reveals 5-year overall survival of 78.1% in pediatric high-risk APL, indicating ongoing challenges with early death risk factors.

Clinical characteristics and outcome of pediatric patients with high-risk acute promyelocytic leukemia, with special focus on risk factors of early death

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical characteristics and outcome of pediatric patients with high-risk acute promyelocytic leukemia, with special focus on risk factors of early death

Discussion

Member takes

Implication

Key Points

Cite This Study

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