August 13, 2025Journal of DiabetesOpen Access

No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study

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No link was found between metabolic disruptions and either aspartame or saccharin intake, suggesting these sweeteners are safe.
In a cohort of 2160 participants, methods included liquid chromatography and mass-spectrometry to assess 549 metabolites.
Generalized linear regression identified associations with heavy aspartame intake and some metabolites, though no significant disruptions were observed.
Findings indicate no metabolic perturbations associated with regular consumption of artificial sweeteners like aspartame and saccharin.

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Observational analysis found no metabolic disruptions from aspartame or saccharin in 2160 young adults, implying safety for these sweeteners.

Steffen et al. (2025) studied this question.

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Observational analysis found no metabolic disruptions from aspartame or saccharin in 2160 young adults, implying safety for these sweeteners.