August 14, 2025CytoJournalOpen Access

1α, 25-dihydroxyvitamin D3 attenuates tumor necrosis factor-α-induced endothelial cell injury by modulating the tumor necrosis factor-α/nuclear factor kappa-B pathway

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Authors

YXYangyang XiaNational Clinical Research SLSixiu LiuChinese Academy of Sciences QSQiuyuan ShaoNanjing Drum Tower Hospital

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Implication

In vitro analysis shows that 1α, 25(OH)2D3 reduces VCAM-1 and E-selectin in endothelial cells, implying its potential in treating cardiovascular diseases.

Key Points

1α, 25(OH)2D3 significantly inhibits TNF-α-induced VCAM-1 and E-selectin expression in endothelial cells, indicating its protective effect.
The treatment reduced the activation of nuclear factor kappa-B signaling, lowering p65 expression and its binding to gene promoters.
ChIP assays confirmed that TNF-α enhanced p65 binding to VCAM-1 and E-selectin promoters, which was reversed by 1α, 25(OH)2D3.
The findings suggest that regulating the TNF-α/NF-κB pathway with vitamin D could benefit patients with cardiovascular diseases.

Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/68a363510a429f797332a5bf https://doi.org/10.25259/cytojournal_220_2024

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August 14, 2025CytoJournalOpen Access

1α, 25-dihydroxyvitamin D3 attenuates tumor necrosis factor-α-induced endothelial cell injury by modulating the tumor necrosis factor-α/nuclear factor kappa-B pathway

View Full Paper

Ask AI

Bookmark

Authors

YXYangyang XiaNational Clinical Research SLSixiu LiuChinese Academy of Sciences QSQiuyuan ShaoNanjing Drum Tower Hospital

Discussion

Member takes

Implication

In vitro analysis shows that 1α, 25(OH)2D3 reduces VCAM-1 and E-selectin in endothelial cells, implying its potential in treating cardiovascular diseases.

Key Points

1α, 25(OH)2D3 significantly inhibits TNF-α-induced VCAM-1 and E-selectin expression in endothelial cells, indicating its protective effect.
The treatment reduced the activation of nuclear factor kappa-B signaling, lowering p65 expression and its binding to gene promoters.
ChIP assays confirmed that TNF-α enhanced p65 binding to VCAM-1 and E-selectin promoters, which was reversed by 1α, 25(OH)2D3.
The findings suggest that regulating the TNF-α/NF-κB pathway with vitamin D could benefit patients with cardiovascular diseases.

Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/68a363510a429f797332a5bf https://doi.org/10.25259/cytojournal_220_2024

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