Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 14, 2025Cellular and Molecular Life SciencesOpen Access

RER1 regulates lipid metabolism in monocytes and macrophages

View Full Paper
Ask AI
Bookmark
Share

Authors

YLYanxia LiuNingxia Medical UniversitySTSandra TheilUniversity Hospital BonnMYMohamed YaghmourUniversity of Bonn

Discussion

Loading...

Member takes

Implication

Experimental findings reveal RER1 influences lipid metabolism in THP-1 cells, indicating its role in immune cell function.

Key Points

  • RER1 deficiency leads to lipid droplet accumulation in monocytes and macrophages, disrupting lipid metabolism.
  • Mass spectrometry analysis shows significant alterations in cellular lipid profiles due to RER1 loss.
  • RNA sequencing highlights RER1's involvement in regulating key genes associated with lipid metabolism.
  • Western immunoblotting confirms the impact of RER1 on the expression of critical proteins for lipid processing.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68a3635e0a429f797332a6ffhttps://doi.org/10.1007/s00018-025-05817-3
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits2010 · 48 citations
  2. 2Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function2024 · 4 citations
  3. 3Cytosolic lipid droplets: From mechanisms of fat storage to disease2014 · 116 citations
  4. 4Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice2011 · 388 citations
  5. 5Very-low and low-density lipoproteins induce neutral lipid accumulation and impair migration in monocyte subsets2016 · 32 citations