August 14, 2025The CerebellumOpen Access

Best Oculomotor Endpoints for Clinical Trials in Hereditary Ataxias: A Systematic Review and Consensus by the Ataxia Global Initiative Working Group on Digital‑Motor Biomarkers

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Authors

EPElena PretegianiUniversity of Siena PGPilar GarcésRoche (Switzerland)CAChrystalina A. AntoniadesJohn Radcliffe Hospital

Discussion

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Implication

Systematic review highlights effective oculomotor and vestibular outcomes for trials in hereditary ataxias, suggesting improved assessments of disease progression.

Key Points

Promising oculomotor outcomes may enhance clinical trials for hereditary ataxias and gauge disease severity effectively.
Of 130 articles reviewed, 2,018 subjects across various hereditary ataxias were assessed for oculomotor/vestibular outcomes.
Established harmonized methodology aids in quantitative assessments, yet further validation for endpoints is essential.
Prospective studies are needed to characterize oculomotor/vestibular outcomes for trials targeting multiple hereditary ataxias.

Cite This Study

Pretegiani et al. (2025) studied this question.

synapsesocial.com/papers/68a3635e0a429f797332a718 https://doi.org/10.1007/s12311-025-01894-z

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Implication

Systematic review highlights effective oculomotor and vestibular outcomes for trials in hereditary ataxias, suggesting improved assessments of disease progression.

Best Oculomotor Endpoints for Clinical Trials in Hereditary Ataxias: A Systematic Review and Consensus by the Ataxia Global Initiative Working Group on Digital‑Motor Biomarkers

Discussion

Member takes

Implication

Key Points

Cite This Study

Best Oculomotor Endpoints for Clinical Trials in Hereditary Ataxias: A Systematic Review and Consensus by the Ataxia Global Initiative Working Group on Digital‑Motor Biomarkers

Discussion

Member takes

Implication

Key Points

Cite This Study

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