August 14, 2025Parasite ImmunologyOpen Access

IL‐12 and IFN‐γ in Response to Leishmania Infantum Antigens in Felines From an Endemic Area for Visceral Leishmaniasis

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Discussion

Observational analysis shows IL-12 and IFN-γ enhance immune response in asymptomatic cats, suggesting protective roles against leishmaniasis.

Felines show higher serum levels of IL-12 and IFN-γ when infected by Leishmania spp., indicating an enhanced immune response.
IL-12 positively correlates with IFN-γ levels, which may help activate immunity against the parasite.
Serum analysis of asymptomatic cats compared to uninfected controls reveals significant differences aligned with leishmaniasis infection.
These findings highlight the potential for immunotherapeutic approaches to reduce leishmaniasis progression and transmission in cats.

Lode et al. (2025) studied this question.

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Observational analysis shows IL-12 and IFN-γ enhance immune response in asymptomatic cats, suggesting protective roles against leishmaniasis.