Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts
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Discussion
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Implication
Observational analysis demonstrates SPOCD1's role in promoting metastasis in colorectal cancer, highlighting its interaction with cancer-associated fibroblasts.
Key Points
- SPOCD1 promotes liver metastasis in colorectal cancer by enhancing CXCL12 expression in cancer-associated fibroblasts.
- Bioinformatics and experimental validation revealed a correlation between SPOCD1 and CAFs infiltration in the tumor microenvironment.
- Analysis using murine models demonstrated the pro-metastatic role of SPOCD1 and its effect on CXCR4 signaling in CRC cells.
- SPOCD1 regulates LAMA4 expression through DNMT1 recruitment, indicating its potential as a therapeutic target.
Cite This Study
Geng et al. (2025) studied this question.