Fifth edition WHO classification: mature B-cell neoplasms

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Review highlights updates in B-cell neoplasms and diagnostic criteria in resource-limited settings, suggesting improved classification methods.

Updates in the WHO classification provide essential and desirable diagnostic criteria for various B-cell neoplasms, enabling better categorization.
The hierarchical structure of the classification allows for family-level diagnoses when specific entity criteria are unmet, aiding in resource-limited conditions.
Analysis considers the impact of genomic technologies on the definitions of mature B-cell neoplasms, enhancing understanding and flexibility.
Emphasis is placed on applying WHO-HAEM5 in diverse settings to ensure accurate diagnosis and effective patient management.

Naresh et al. (2025) studied this question.

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Review highlights updates in B-cell neoplasms and diagnostic criteria in resource-limited settings, suggesting improved classification methods.