Retrospective analysis highlights that de-escalation of anti-MRSA therapy occurs rapidly in critically ill patients, suggesting stewardship opportunities.
In this retrospective study, critically ill patients with community-acquired pneumonia frequently received empiric anti-methicillin-resistant Staphylococcus aureus (MRSA) and antipseudomonal antibiotics despite having few or no guidelines-endorsed risk factors. De-escalation of anti-MRSA therapy was quicker, likely aided by MRSA polymerase chain reaction assays.
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Trujillo et al. (2025) studied this question.
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