Bimolecular Nucleophilic Substitution (SN2) Reaction Catalyzed by l-Threonine Aldolase

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Reported new activity enables direct asymmetric alkylation in glycine, suggesting aldolases can catalyze SN2 reactions effectively.

The repurposed l-threonine aldolase catalyzes an SN2 reaction, achieving yields up to 95%.
The study highlights 29 examples of enantiomerically enriched α-amino acids synthesized efficiently.
Computational analysis demonstrates how enzyme active sites align substrates for SN2 transition states.
This finding expands the catalytic repertoire of aldolases, underscoring their potential in sustainable synthesis.

Yang et al. (2025) studied this question.

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