Clinical and Patient-Reported Outcomes After Mix-and-Match Implantation of a Trifocal and Non-Diffractive Extended Depth of Focus IOL

To evaluate cataract surgery outcomes following mix-and-match implantation of a trifocal and extended-depth-of-focus (EDOF) intraocular lens (IOL). Single center, private practice. Single arm, non-interventional, ambispective study. Patients who underwent femtosecond-laser assisted cataract surgery with mix-and-match implantation of the Clareon PanOptix trifocal IOL in the non-dominant eye and Clareon Vivity EDOF IOL in the dominant eye from September 2022 to November 2023 were reviewed. Only healthy eyes with postoperative absolute spherical equivalent (SE) ≤ 0.50 diopters (D) and cylinder ≤ 0.75 D were included. At 3 months postoperatively, binocular corrected and uncorrected visual acuity at distance (CDVA and UDVA), intermediate (DCIVA and UIVA), and near (DCNVA and UNVA) along with patient-reported outcomes (QUVID and IOLSAT questionnaires) were assessed. 100 eyes of 50 patients were included. Postoperatively, the mean binocular CDVA and UDVA was -0.08 ± 0.05 logMAR and -0.06 ± 0.05 logMAR, respectively. Overall, 100%, 98%, and 90% of patients achieved binocular UDVA, UIVA, and UNVA of 20/25 or better, respectively. Eighty-four percent of patients reported complete spectacle independence. Few patients were "bothered very much" by haloes, glare, or starbursts (0-4%). No patients reported dissatisfaction with their vision. Overall, 94% and 92% of patients would elect the same IOLs and recommend the same procedure to friends and family, respectively. Mix-and-match implantation of the Clareon PanOptix and Vivity IOLs yields good patient satisfaction potentially by combining the advantages of each lens resulting in a high degree of satisfaction and low rates of visual disturbances.