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August 15, 2025MaterialsOpen Access

In Vitro Bioactivity and Cytotoxicity Assessment of Two Root Canal Sealers

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Authors

YYYicheng YeSHSepanta HosseinpourJWJuan Wen

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Overview

Investigation highlights cytotoxicity and biocompatibility of calcium silicate-based sealers in hPDLSCs, suggesting better tissue regeneration mechanisms.

Key Points

  • EndoSequence BC and AH Plus Bioceramic Sealers improved cell viability and proliferation compared to AH Plus control.
  • Gene expression in both sealers showed significant upregulation of osteogenic markers, indicating enhanced regenerative potential.
  • Assessment via MTT, Live/Dead, and wound healing assays indicates strong biocompatibility for both sealers compared to traditional options.
  • Findings imply that while in vitro results are promising, further ex vivo studies are necessary for clinical application.

Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/68a365600a429f797332b5behttps://doi.org/10.3390/ma18153717
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