Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

Interest in enaminomaleimides has grown significantly over the past decades, as they have proven to be versatile building blocks for the synthesis of functionalized heterocycles. Their unique nucleophilic character, in contrast to the classical electrophilic nature of maleimides, has unlocked new synthetic possibilities, enabling their application across a wide range of chemical transformations. Moreover, their potential extends beyond synthetic chemistry, with promising results reported in both materials science and medicinal chemistry. This review provides a comprehensive overview of the synthesis and chemical applications of enaminomaleimides over time, while also highlighting emerging trends and future directions in this rapidly evolving field.