August 15, 2025Open Access

Ultra-parallel ribosome profiling platform with RNA-dependent RNA amplification

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Ribosome profiling enhances translation study in human samples, suggesting links to COVID-19 symptoms.

The platform enabled analysis of translation from numerous samples with lower input amounts.
Key findings include links between stop codon readthrough, mitochondrial translation deficiency, and COVID-19 severity.
Assessment involved a semi-automated ribosome profiling method combined with RNA-dependent RNA amplification.
This approach highlights new factors influencing translation regulation and ribosome quality control.

Shichino et al. (2025) studied this question.

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