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August 15, 2025International Journal of Molecular SciencesOpen Access

Bacteriophages, Antibiotics and Probiotics: Exploring the Microbial Battlefield of Colorectal Cancer

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Authors

CVCristian Constantin VolovățGrigore T. Popa University of Medicine and PharmacyMCMihai Andrei CosovanuAthens EuroclinicMOMădălina-Raluca OstafeGrigore T. Popa University of Medicine and Pharmacy

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Implication

Analysis shows the impact of bacteriophages and probiotics on gut microbiome dynamics in colorectal cancer, suggesting treatment avenues.

Key Points

  • The gut microbiome influences colorectal cancer risk and progression, with bacteriophages playing a crucial role in maintaining its balance.
  • Perturbations in the gut microbiome can lead to inflammation and DNA damage, contributing to colorectal cancer development.
  • Bacteriophages can be harnessed for targeted drug delivery, potentially enhancing treatment outcomes in colorectal cancer patients.
  • Antibiotics can induce dysbiosis, which may complicate colorectal cancer therapy, highlighting the need for probiotics as adjunctive treatment.

Cite This Study

Volovăț et al. (2025) studied this question.

synapsesocial.com/papers/68a366930a429f797332bf22https://doi.org/10.3390/ijms26167837
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Also Consider

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  1. 1The Intestinal Microbiota and Metabolites in the Gut-Kidney-Heart Axis of Chronic Kidney Disease2022 · 100 citations
  2. 2Colorectal cancer: role of commensal bacteria and bystander effects2015 · 47 citations
  3. 3Gut microbiota and aging.2018 · 71 citations
  4. 4Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by Helicobacter pylori infection2023 · 26 citations
  5. 5Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis2018 · 412 citations