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August 15, 2025Asian Journal of Organic ChemistryOpen Access

The Synthesis of Nonsymmetric α‐hydroxy‐ethylidenebisphosphonic Derivatives by the Pudovik Reaction, Their Reactions, and Cytotoxic Activity

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Authors

ZSZsuzsanna SzalaiBudapest University of Technology and EconomicsBTBoldizsár TóthBudapest University of Technology and EconomicsCHCsaba HorváthNational University of Ireland, Maynooth

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Implication

Synthesis reports strong cytotoxic activity of new α‐hydroxy‐ethylidenebisphosphonic derivatives in cancer cell lines, indicating therapeutic potential.

Key Points

  • The new α‐hydroxy‐ethylidenebisphosphonic derivatives showed significant cytotoxic effects on cancer cell lines.
  • Dibutyl 1‐(butyl‐phenylphosphinoyl)‐1‐hydroxy‐ethylphosphonate and tetrabutyl α‐acetyloxy‐ethylidenebisphosphonate reduced U266 cell viability by 94% and 91%, respectively.
  • Synthesis was achieved through the Pudovik reaction using dialkyl α‐oxo‐ethylphosphonates and various P‐reagents.
  • Enhancement in anticancer activity was confirmed through cytotoxic screening on multiple myeloma and metastatic melanoma cell lines.

Cite This Study

Szalai et al. (2025) studied this question.

synapsesocial.com/papers/68a366930a429f797332c137https://doi.org/10.1002/ajoc.202500596
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