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August 16, 2025Open Access

Establishment of a humanized patient-derived xenograft mouse model of high-grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

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Authors

LTLuka TandarićLBLine BjørgeMLMartine Lode

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Overview

A humanized patient-derived xenograft model reveals immune-excluded tumors in high-grade serous ovarian cancer, suggesting limited immunotherapy efficacy.

Key Points

  • No responses to immunotherapy were observed in the patient-derived xenograft model of high-grade serous ovarian cancer, indicating challenges in treatment effectiveness.
  • Correlation between tumor burden and T-cell densities was significant in the durvalumab-only group, highlighting potential immunotherapy dynamics.
  • This observational analysis involved a humanized mouse model that reflects human disease biology and immune interactions.
  • Findings emphasize the need for better models to study immunosuppressive mechanisms affecting high-grade serous ovarian cancer.

Cite This Study

Tandarić et al. (2025) studied this question.

synapsesocial.com/papers/68a366a20a429f797332c565https://doi.org/10.1101/2025.08.08.669244
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy2026
  2. 2Transcriptome profiling and characterization of peritoneal metastasis ovarian cancer xenografts in humanized mice2024
  3. 3Abstract A085: Evaluating the immune modulating effects of standard chemotherapies and macrophage-targeted therapy in a humanized patient-derived xenograft model of high grade ovarian cancer2024
  4. 4Abstract PR-009: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer using human multicellular in vitro models2024
  5. 5Abstract 4187: Transcriptome profiling and characterization of peritoneal metastasis ovarian cancer xenografts in humanized mice2024