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Mathematical Model of Drug-Resistant Malaria and Typhoid Fever Co-Infection With Optimal Control and Cost Effectiveness Analysis

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Preventing drug-resistant malaria significantly decreases the spread of co-infections, which is crucial for public health.
Numerical simulations reveal that targeting prevention of typhoid from all sources is the most cost-effective strategy.
The model introduces compartments for individuals with both infections, highlighting their role in disease dynamics.
This combined approach could offer substantial reductions in disease burden at minimal costs.

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Deterministic model shows that preventing drug-resistant malaria reduces co-infection rates, suggesting cost-effective interventions.

Ofomata et al. (2025) studied this question.

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