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August 16, 2025Frontiers in MicrobiologyOpen Access

Zhi-zi-chi decoction exerts hypnotic effect through gut-brain axis modulation in insomnia mice

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Authors

QWQianqian WangNaval Medical Research CommandBZBoyi ZhangGerman Sport University CologneZGZixuan GuoCalifornia University of Pennsylvania

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Implication

Experimental analysis demonstrates improved sleep and neurotransmitter balance in insomnia mice, highlighting TCM's potential benefits.

Key Points

  • ZZCD significantly improves sleep quality in insomnia mice, reducing anxiety-like behavior and enhancing overall well-being.
  • Key outcomes included restored levels of GABA and serotonin while reducing glutamate, suggesting balanced neurotransmitter activity.
  • Assessment using a PCPA-induced insomnia model, behavioral tests, and neurotransmitter assays confirmed physiological impacts on sleep.
  • These findings advocate ZZCD as a safe, effective treatment, with implications for neuroprotection and gut health in insomnia management.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68a368710a429f797332d1edhttps://doi.org/10.3389/fmicb.2025.1645190
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