August 16, 2025

Overcoming phage resistance: efficacy of sequential phage-colistin therapy against carbapenem-resistant

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Sequential phage-antibiotic therapy improves bacterial clearance and reduces resistance emergence.
In mouse models, phage monotherapy at optimal doses showed varied survival, with some regrowth due to resistance.
Phage-antibiotic synergy was found, particularly with tigecycline, but effects were temporary and limited.
Sequential administration of colistin after phage treatment significantly enhanced survival rates compared to monotherapy.

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This analysis reveals that sequential phage-antibiotic therapy improves survival in CRAB infections, suggesting a novel treatment strategy.

Choi et al. (2025) studied this question.

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This analysis reveals that sequential phage-antibiotic therapy improves survival in CRAB infections, suggesting a novel treatment strategy.