Palladium-catalyzed α-arylation produces α-arylated nitroalkanes with functionalization and scale-up synthesis options.
Palladium-catalyzed α-arylation of nitroalkanes by utilizing aryl fluorosulfonates as effective arylating agents can be realized. The reactions proceed effectively through C-O bond activation to produce a variety of valuable α-arylated nitroalkanes in modest to good yields with wide functional group compatibility. Additionally, late-stage functionalization of complex molecules and scale-up synthesis can be achieved.
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Zhu et al. (2025) studied this question.
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