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August 16, 2025

Rhodium-Catalyzed 1,1-Arylesterification of Unactivated Alkenes with Dinucleophiles.

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Authors

KMKai-Xian MaJYJiang-Min YanFZFanlong Zeng

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Overview

Rhodium-catalyzed reaction achieves 1,1-difunctionalization in alkenes, highlighting new synthetic pathways.

Key Points

  • 1,1-difunctionalization yields broad structural diversity, improving synthetic efficiency.
  • Rhodium(III) catalysis promotes selective C-C bond cleavage with high functional group tolerance.
  • Sequential insertion and elimination steps enable complex product formation with two nucleophiles.
  • Mechanistic studies reveal critical pathways including C(sp3)-C(sp2) bond breaking and hydride reinsertion.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68a368840a429f797332da82https://doi.org/10.1021/acs.orglett.5c02585
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