Utility of a green synthesized NiO nanoparticles sensor for the determination of triprolidine hydrochloride in pure form and commercial products.

In this study, an environmentally friendly biomethod was developed for the green synthesis of nickel oxide nanoparticles (NiONPs) by lemon balm extract due to its bioreductive ability , this process is completely green, and free of toxic and hazardous solvents ,the optical, catalytic and structural properties of NiONPs were studied, through the use of XRD and SEM measurement, the results showed the formation of pure and crystalline NiONPs, we also manufactured electrodes for the determination of the drug triprolidine hydrochloride (TRI), the first electrode is the traditional coated graphite electrode (I) (TRI-PTA-TBP), as for the second electrode, the nano-coated graphite electrode (II) (TRI-PTA-TBPNiONPs), the results showed that the linear range for the conventional selectivity of electrode (I) is between (10-2 – 10-6) mol/L, while the linear range for the nanoelectrode (II) is between (10-2 – 10-8) mol/L, and the inclination of electrode (I) was calculated at (54.5) millivolts/knot, while the inclination of electrode (II) was estimated at (58.25) millivolts/knot, the results also showed that the estimation factor for electrode (I (is (0.9991), while the estimation factor for the electrode (II) is (0.9999), through these results, we have concluded that the graphite electrode coated with nickel nanoparticles (II) is more sensitive and selective than the traditional coated graphite electrode (I),these poles succeeded in identifying (TRI) In its various pharmaceutical formulations, the validation of the method was evaluated according to IUPAC recommendations as this method is an environmentally friendly technology and does not require sample pretreatment or derivatization.