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August 17, 2025Journal of Diabetes ResearchOpen Access

Clinical and Pathological Characteristics and Prognosis of Diabetic Nephropathy Patients With Tertiary Lymphoid Structures

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Authors

YZYongjie ZhuoMWMengjie WengJLJiaqun Lin

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Overview

Cohort analysis reveals TLS maturity correlates with worse renal prognosis in patients with diabetic nephropathy, suggesting personalized risk management strategies.

Key Points

  • Mature tertiary lymphoid structures independently predict worse renal prognosis in diabetic nephropathy patients.
  • Patients with mature TLSs showed a disease progression rate of 75.4%, compared to 53.3% in those without, highlighting a significant disparity.
  • Observational analysis of biopsy-confirmed diabetic nephropathy cases utilized Cox regression and Kaplan–Meier methods to assess renal survival.
  • These findings underscore the importance of TLS characteristics in renal function decline, indicating potential for tailored risk assessments.

Cite This Study

Zhuo et al. (2025) studied this question.

synapsesocial.com/papers/68a36a3f0a429f797332e9f1https://doi.org/10.1155/jdr/6916580
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Progression of diabetic nephropathy and adverse renal outcomes: possible involvement of Toll-like receptor 4 expression2026
  2. 2Immature central tumor tertiary lymphoid structures are associated with better prognosis in non-small cell lung cancer2024 · 13 citations
  3. 3Clinical and immunological significance of tertiary lymphoid structure maturation heterogeneity in brain metastases of lung adenocarcinoma2026 · 1 citations
  4. 4Density and Maturity of Tertiary Lymphoid Structures Predict Clinical Outcome in Invasive Lung Adenocarcinoma2025
  5. 5A Tertiary Lymphoid Structure–Derived Prognostic Signature Integrates Immune Microenvironment and Mutational Landscapes in Clear Cell Renal Cell Carcinoma2026 · 1 citations