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August 17, 2025PharmaceuticsOpen Access

Therapeutic pCRISPRi Delivery to Lung Squamous Cell Carcinoma by Combining Nanobubbles and Ultrasound

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Therapeutic CRISPR interference induces apoptosis and reduces tumor growth in lung SCC, suggesting effective delivery methods.

Nanobubbles and ultrasound delivery significantly suppress tumor growth and induce apoptosis in lung SCC.
In a lung SCC xenograft model, the treatment led to substantial tumor volume reduction observed over several days.
Assessment used intratumoral pCRISPRi delivery via nanobubbles followed by ultrasound to enhance uptake effectiveness.
This approach highlights a potential for targeted therapy in other cancers by adapting the delivery technique and targeting factors.

Yamaguchi et al. (2025) studied this question.

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