Reversibility of Adaptation, Phenomena of Physiological and Pathological Maladaptation

The possibility of a reverse development of the process of long-term adaptation is expressed in the gradual disappearance of adaptation to physical exertion, hypoxia, and chemical factors after the cessation of these factors. It has been shown that at this time there is a rather rapid disappearance of the systemic structural trace that forms the basis of each of these adaptation options (a decrease in skeletal muscle mass, the number of mitochondria in them, a decrease in lung and heart muscle mass after cessation of physical exertion, a decrease in the mass of the right ventricle of the heart and the gradual disappearance of polycythemia after the body leaves hypoxia, a decrease in activity of the microsomal oxidation system and liver mass after discontinuation of the administration of poisons).