Synthesis of photoswitchable desloratadine ligands enhances photopharmacology in histamine H1 receptors, suggesting new therapeutic approaches.
Despite the pharmacological relevance of the histamine H 1 receptor (H 1 R), the second most therapeutically targeted G protein-coupled receptor (GPCR), an effective photoswitchable ligand to optically control this receptor remains elusive....
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Binkhorst et al. (2025) studied this question.
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