Development and validation of new spectrophotometric methods for the estimation of Risperidone

Risperidone is an anti-psychotic drug used for the treatment of mood and mental health conditions including schizophrenia and bipolar disorders. New spectrophotometric methods have been proposed for the estimation of Risperidone in pharmaceutical dosage forms using Shimadzu Model UV-1800 Double beam UV-VIS spectrophotometer. Risperidone has shown linearity over the concentration range 1-50 µg/ml in phosphate buffer (pH 7.0), acetate buffer (pH 4.0) and phosphate buffer (pH 7.5) and the methods were validated as per ICH guidelines. The proposed methods are simple, economical and can be successfully applied for the assay of Risperidone in tablet dosage forms.