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August 17, 2025Frontiers in OncologyOpen Access

Unraveling the potential: mRNA therapeutics in oncology

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Review shows mRNA enhances immune response in tumor treatments, suggesting potential in personalized cancer vaccines.

mRNA-based therapies show promise in improving immune response against cancer and tumor antigens, with various methods under investigation.
Early-phase clinical trials indicate safety and efficacy for mRNA treatments targeting malignancies like melanoma and lung cancer.
Analysis of mRNA therapy evolution highlights advancements, including personalized vaccines targeting unique neoantigens in individual tumors.
Combination of mRNA vaccinations with treatments like immune checkpoint inhibitors may represent a novel approach in oncology.

Gawalski et al. (2025) studied this question.

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