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August 17, 2025Frontiers in OncologyOpen Access

Analysis of the safety and efficacy of PD-1/PD-L1 inhibitors combined with chemotherapy in the treatment of locally advanced resectable esophageal squamous cell carcinoma: a systematic review and meta-analysis based on four randomized controlled trials

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Authors

TLTao LuoHYHao YangXRXianhui Ran

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Overview

Meta-analysis compares neoadjuvant chemoimmunotherapy and neoadjuvant chemotherapy in esophageal cancer, indicating potential safety and efficacy benefits.

Key Points

  • Neoadjuvant chemotherapy combined with immunotherapy significantly prolongs surgery intervals compared to chemotherapy alone, enhancing treatment efficacy.
  • Patients receiving the combination therapy showed a 3.44-fold increase in pathological complete response rates, underscoring improved outcomes.
  • Analysis of four randomized controlled trials involving 629 participants confirms positive efficacy, but highlights anemia as a notable adverse reaction.
  • Further large-scale randomized controlled trials are required to validate findings, particularly given the absence of long-term follow-up data.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/68a36a4f0a429f797332efabhttps://doi.org/10.3389/fonc.2025.1590111
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The safety and efficacy of neoadjuvant immunochemotherapy in locally advanced esophageal squamous cell carcinoma: a meta-analysis and systematic review2026 · 1 citations
  2. 2Safety and feasibility of esophagectomy following neoadjuvant immunotherapy combined with chemotherapy or chemoradiotherapy for locally advanced esophageal squamous cell carcinoma: Analysis of two phase 2 clinical trials.2024 · 2 citations
  3. 3Safety and short-term outcomes of esophagectomy after neoadjuvant immunotherapy combined with chemotherapy or chemoradiotherapy for locally advanced esophageal squamous cell cancer: analysis of two phase-II clinical trials2024 · 5 citations
  4. 4Efficacy of neoadjuvant chemoimmunotherapy in locally advanced resectable esophageal cancer2025 · 1 citations
  5. 5Neoadjuvant immunotherapy combined with concurrent chemoradiotherapy for locally advanced esophageal squamous cell carcinoma: A prospective, single-arm, phase II trial.2026